CCI Calculator

Corrected Count Increment for platelet transfusion response assessment

Educational Tool Only. This calculator is for educational purposes. Clinical decisions should be made in consultation with transfusion medicine specialists.

CCI = (Post - Pre) × BSA / Platelets × 1,000

Pre-transfusion Count (×10⁹/L)

Post-transfusion Count (×10⁹/L)

BSA (m²)

Platelets Transfused (×10¹¹)

CCI Thresholds & Interpretation

Timepoint	Adequate Response	Inadequate Response
1-Hour CCI	≥7,500	<7,500
24-Hour CCI	≥4,500	<4,500

Pattern Interpretation

Poor 1hr + Poor 24hr

Suggests alloimmune cause (HLA/HPA antibodies). Consider HLA antibody testing and HLA-matched/crossmatch-compatible platelets.

Good 1hr + Poor 24hr

Suggests non-immune cause (infection, DIC, splenomegaly). Address underlying consumptive factors.

Good 1hr + Good 24hr

Adequate response. Continue standard platelet transfusions as clinically indicated.

Note: Platelet refractoriness is defined as 2+ consecutive inadequate responses after transfusion of ABO-compatible, fresh (<72 hours old) platelets.