HLA-Selected Breakeven Calculator

Cost-effectiveness analysis for HLA-selected vs standard platelet transfusions

Educational Tool Only. This calculator is for educational purposes and cost estimation. Actual costs vary by institution. Clinical decisions should involve transfusion medicine specialists.

Compare total costs when you know both the standard and HLA-selected success rates.

Standard Platelet Cost ($)

HLA-Selected Surcharge ($)

Standard Success Rate (%)

HLA-Selected Success Rate (%)

Expected # of Effective Transfusions

Calculate the minimum HLA-selected success rate needed to justify the added cost.

Standard Platelet Cost ($)

HLA-Selected Surcharge ($)

Standard Success Rate (%)

When HLA-Selected Platelets Are Cost-Effective

Favorable Scenarios

High PRA (>50%) with multiple HLA antibodies
Frequent transfusion needs (>2/week)
Consistently poor response to standard platelets
Low HLA surcharge relative to standard cost
Available HLA-matched donors with good match grades (A, B1U)

Unfavorable Scenarios

Low PRA or no detectable HLA antibodies
Infrequent transfusion needs
Non-immune factors predominate (infection, DIC)
Very high HLA surcharge
Only poor HLA match grades available (C, D)

Success Rate Reference: Grade A HLA matches typically achieve 70-90% success, Grade B1U 65-85%, while standard platelets in refractory patients may only achieve 20-40%.