Transfusion Reaction Guide

Evidence-based classification and management of transfusion reactions

FOR EDUCATIONAL USE ONLY

This tool is for educational purposes only and is not FDA-evaluated. It should not replace clinical judgment. All transfusion reactions require assessment by qualified healthcare professionals following institutional protocols.

When did symptoms begin?
During Transfusion
While blood is infusing
0-4 Hours
Acute post-transfusion
4-24 Hours
Early delayed
1-28 Days
Delayed reaction
Select Signs & Symptoms

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Clinical Context

These factors help distinguish between similar reactions (e.g., TRALI Type I vs II, TACO vs TRALI)

ARDS Risk Factor Present?
Sepsis, pneumonia, aspiration, trauma, etc.
Respiratory Stable Before Transfusion?
For TRALI Type II assessment
BNP/NT-proBNP Elevated?
Suggests TACO over TRALI
DAT Positive (New/Stronger)?
Suggests hemolytic reaction
Blood Cultures Positive?
Suggests septic reaction

Select Symptoms to Begin

Choose the signs and symptoms observed, then click "Classify Reaction" to see the differential diagnosis and management recommendations.

Reaction Types

Select a Reaction Type

Choose a reaction from the list to view detailed information, case identification criteria, and management protocols.

Red Flags - STOP Transfusion Immediately
Always Rule Out First
TRALI vs TACO - Key Differences
Immediate Actions - All Reactions