Blood Bank Workup Guide

Decision support for antibody identification, ABO/Rh discrepancies, and WBIT investigation

v1.0.0
FOR EDUCATIONAL USE ONLY

This tool is for EDUCATIONAL USE ONLY. It is not a validated medical device and should not be used for clinical decision-making without verification against your institution's validated procedures and medical director approval.

WBIT Investigation

Wrong Blood in Tube (WBIT) must be investigated whenever a type discrepancy is detected. Patient safety is paramount - never release blood products until resolved.

Key Principle CRITICAL

Always collect a new specimen before releasing blood products when a type discrepancy is detected.

Investigation Triggers

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Investigation Steps

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ABO Discrepancy Resolution

ABO discrepancies occur when forward and reverse typing don't match, or when current results differ from historical records.

Group I - Extra Reverse Reactions

Unexpected agglutination with A1/B cells

Group II - Weak/Missing Forward

Weak or absent A/B antigens

Group III - Missing Reverse

Weak or absent anti-A/anti-B

Group IV - Mixed/Complex

Mixed field or complex patterns

Rh(D) Discrepancy Resolution

Rh(D) typing discrepancies require investigation to ensure appropriate product selection and RhIG prophylaxis decisions.

Weak D

Reduced D expression (quantitative)

Partial D

Missing epitopes - can make anti-D

DEL

Extremely weak D expression

Antibody Identification Workup

Guidelines for antibody identification including rule criteria, enhancement techniques, and special considerations.

References